Are people with family history of pancreatic cancer enriched with genetic propensity for diabetes mellitus?

Observational studies suggest that long-standing diabetes may be a cause of pancreatic cancer. To further support this observation, we aimed to determine whether the genetic risk of diabetes is associated with a family history of pancreatic cancer (FH+) in persons without a personal history of pancreatic cancer. We hypothesized that if diabetes is a cause of pancreatic cancer, then persons with a FH+, reflecting both inheritance and lifestyle risk factors, will be enriched with a genetic propensity for diabetes. Our hypothesis assumes that the causal genes for diabetes and pancreatic cancer are not identical.